Drug interactions
Cyclosporin + Naloxegol
Severity: Moderate
Cyclosporin and Naloxegol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits CYP3A4 and P-gp and can raise naloxegol exposure. This may cause opioid withdrawal symptoms and gastrointestinal adverse effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Cyclosporin and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP3A4 and P-gp reduces naloxegol metabolism and efflux.
What to do
Reduce naloxegol to 12.5 mg daily if the combination is necessary. Monitor for withdrawal symptoms and abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Cyclosporin with Naloxegol?
MediHelp rates the interaction as moderate. Cyclosporin and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits CYP3A4 and P-gp and can raise naloxegol exposure. This may cause opioid withdrawal symptoms and gastrointestinal adverse effects such as abdominal pain and diarrhea.
How serious is the interaction between Cyclosporin and Naloxegol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce naloxegol to 12.5 mg daily if the combination is necessary. Monitor for withdrawal symptoms and abdominal pain.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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