Drug interactions
Cyclosporin + Nimodipine
Severity: Moderate
Cyclosporin and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can increase nimodipine concentrations, leading to hypotension, flushing, headache or edema. This is relevant in subarachnoid hemorrhage where blood pressure control matters for cerebral perfusion.
What this interaction means in plain words
Cyclosporin and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Nimodipine belongs to Cardiovascular.
Why it happens
Cyclosporine inhibits intestinal and hepatic CYP3A4, reducing nimodipine first-pass metabolism.
What to do
Monitor blood pressure closely and reduce the nimodipine dose or split dosing if hypotension occurs. Monitor cyclosporine levels as well.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclosporin and Nimodipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Cyclosporin with Nimodipine?
MediHelp rates the interaction as moderate. Cyclosporin and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can increase nimodipine concentrations, leading to hypotension, flushing, headache or edema. This is relevant in subarachnoid hemorrhage where blood pressure control matters for cerebral perfusion.
How serious is the interaction between Cyclosporin and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and reduce the nimodipine dose or split dosing if hypotension occurs. Monitor cyclosporine levels as well.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
