Drug interactions
Cyclosporin + Pneumococcal vaccine 13-valent
Severity: Moderate
Cyclosporin and Pneumococcal vaccine 13-valent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine suppresses T-cell function and can reduce the antibody response to pneumococcal conjugate vaccine. Patients may have weaker or shorter-lived protection.
What this interaction means in plain words
Cyclosporin and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Pneumococcal vaccine 13-valent belongs to Miscellaneous.
Why it happens
Immunosuppression by calcineurin inhibition impairs T-cell dependent immune response to vaccination.
What to do
Vaccinate at least 2 weeks before starting immunosuppression when feasible. Otherwise still vaccinate, since the vaccine is non-live, and consider checking titers or revaccinating after immune recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Cyclosporin with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as moderate. Cyclosporin and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine suppresses T-cell function and can reduce the antibody response to pneumococcal conjugate vaccine. Patients may have weaker or shorter-lived protection.
How serious is the interaction between Cyclosporin and Pneumococcal vaccine 13-valent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before starting immunosuppression when feasible. Otherwise still vaccinate, since the vaccine is non-live, and consider checking titers or revaccinating after immune recovery.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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