Drug interactions
Cyclosporin + Propafenone
Severity: Moderate
Cyclosporin and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone is metabolized by CYP2D6, CYP3A4 and CYP1A2, and CYP3A4 inhibition by cyclosporine may raise its levels. Propafenone can also increase cyclosporine concentrations in some reports. Elevated propafenone exposure carries a risk of proarrhythmia and conduction disturbances.
What this interaction means in plain words
Cyclosporin and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Propafenone belongs to Cardiovascular.
Why it happens
Cyclosporine inhibits CYP3A4 metabolism of propafenone, and propafenone may in turn alter cyclosporine levels.
What to do
Monitor ECG and cyclosporine trough concentrations when starting or stopping either drug. Reduce the propafenone dose if QRS widening or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclosporin and Propafenone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Cyclosporin with Propafenone?
MediHelp rates the interaction as moderate. Cyclosporin and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone is metabolized by CYP2D6, CYP3A4 and CYP1A2, and CYP3A4 inhibition by cyclosporine may raise its levels. Propafenone can also increase cyclosporine concentrations in some reports. Elevated propafenone exposure carries a risk of proarrhythmia and conduction disturbances.
How serious is the interaction between Cyclosporin and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and cyclosporine trough concentrations when starting or stopping either drug. Reduce the propafenone dose if QRS widening or bradycardia occurs.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
