Drug interactions
Cyclosporin + Pyrazinamide
Severity: Minor
Cyclosporin and Pyrazinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A case report described lower cyclosporine levels after pyrazinamide was added. Evidence is very limited and the effect may reflect other antituberculous drugs such as rifampicin.
What this interaction means in plain words
Cyclosporin and Pyrazinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Pyrazinamide belongs to Anti Bacterial.
Why it happens
Mechanism not established.
What to do
Monitor cyclosporine trough levels when pyrazinamide is started, especially within multidrug tuberculosis regimens, and adjust the dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Pyrazinamide
- Pexidartinib + Pyrazinamide Major
- Pretomanid + Pyrazinamide Major
- Isoniazid + Pyrazinamide Moderate
- Mipomersen + Pyrazinamide Moderate
- Probenecid + Pyrazinamide Moderate
- Pyrazinamide + Rifampin Moderate
Frequently asked questions
Can I take Cyclosporin with Pyrazinamide?
MediHelp rates the interaction as minor. Cyclosporin and Pyrazinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A case report described lower cyclosporine levels after pyrazinamide was added. Evidence is very limited and the effect may reflect other antituberculous drugs such as rifampicin.
How serious is the interaction between Cyclosporin and Pyrazinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels when pyrazinamide is started, especially within multidrug tuberculosis regimens, and adjust the dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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