Drug interactions
Cyclosporin + Quetiapine
Severity: Minor
Cyclosporin and Quetiapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may modestly raise quetiapine concentrations, increasing sedation, orthostatic hypotension and QT effects. The interaction is predicted rather than well documented.
What this interaction means in plain words
Cyclosporin and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Quetiapine belongs to Central Nervous System.
Why it happens
Cyclosporine's weak-to-moderate CYP3A4 inhibition may reduce quetiapine metabolism.
What to do
Monitor for sedation, hypotension and QT effects, and lower the quetiapine dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Cyclosporin with Quetiapine?
MediHelp rates the interaction as minor. Cyclosporin and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporine may modestly raise quetiapine concentrations, increasing sedation, orthostatic hypotension and QT effects. The interaction is predicted rather than well documented.
How serious is the interaction between Cyclosporin and Quetiapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, hypotension and QT effects, and lower the quetiapine dose if adverse effects occur.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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