Drug interactions
Cyclosporin + Quinidine
Severity: Moderate
Cyclosporin and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine has been reported to raise cyclosporine levels, and cyclosporine may affect quinidine exposure. Increased quinidine can cause QT prolongation and arrhythmia, and higher cyclosporine increases nephrotoxicity.
What this interaction means in plain words
Cyclosporin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Quinidine belongs to Anti Parasitic.
Why it happens
Mutual inhibition of P-glycoprotein and CYP3A4 involved in the clearance of both drugs.
What to do
Monitor cyclosporine trough levels, renal function, ECG and quinidine concentrations. Adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Quinidine?
MediHelp rates the interaction as moderate. Cyclosporin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine has been reported to raise cyclosporine levels, and cyclosporine may affect quinidine exposure. Increased quinidine can cause QT prolongation and arrhythmia, and higher cyclosporine increases nephrotoxicity.
How serious is the interaction between Cyclosporin and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels, renal function, ECG and quinidine concentrations. Adjust doses as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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