Drug interactions
Cyclosporin + Sarecycline
Severity: Minor
Cyclosporin and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is a weak P-glycoprotein inhibitor and may slightly raise concentrations of cyclosporine. Because systemic exposure to sarecycline is modest, the effect is usually small but could matter given cyclosporine's narrow therapeutic index.
What this interaction means in plain words
Cyclosporin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Sarecycline belongs to Anti Bacterial.
Why it happens
Weak inhibition of P-glycoprotein efflux of cyclosporine.
What to do
Check cyclosporine trough levels if sarecycline is added and adjust the dose if levels rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Cyclosporin with Sarecycline?
MediHelp rates the interaction as minor. Cyclosporin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is a weak P-glycoprotein inhibitor and may slightly raise concentrations of cyclosporine. Because systemic exposure to sarecycline is modest, the effect is usually small but could matter given cyclosporine's narrow therapeutic index.
How serious is the interaction between Cyclosporin and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check cyclosporine trough levels if sarecycline is added and adjust the dose if levels rise.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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