Drug interactions
Cyclosporin + Seladelpar
Severity: Moderate
Cyclosporin and Seladelpar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine increases seladelpar exposure, raising the potential for dose-related adverse effects.
What this interaction means in plain words
Cyclosporin and Seladelpar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Seladelpar belongs to Gastrointestinal Tract.
Why it happens
Cyclosporine inhibits OATP1B1, OATP1B3 and BCRP, reducing hepatic uptake and efflux of seladelpar.
What to do
Monitor for adverse effects and liver biochemistry while on both drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Seladelpar
- Fluconazole + Seladelpar Moderate
- Rifampicin + Seladelpar Moderate
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Seladelpar?
MediHelp rates the interaction as moderate. Cyclosporin and Seladelpar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine increases seladelpar exposure, raising the potential for dose-related adverse effects.
How serious is the interaction between Cyclosporin and Seladelpar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and liver biochemistry while on both drugs.
What other medicines interact with Seladelpar?
MediHelp also lists interactions of Seladelpar with, for example, Fluconazole, Rifampicin. The full list is on the Seladelpar page.
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