Drug interactions
Rifampicin + Seladelpar
Severity: Moderate
Rifampicin and Seladelpar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin lowers seladelpar concentrations, which may delay or diminish the biochemical response in cholangitis.
What this interaction means in plain words
Rifampicin and Seladelpar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifampicin belongs to Anti Bacterial; Seladelpar belongs to Gastrointestinal Tract.
Why it happens
Rifampicin induces metabolizing enzymes and may alter transporter activity, lowering seladelpar exposure.
What to do
Monitor ALP and bilirubin when rifampicin is started. Evaluate the need for therapy change if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Seladelpar
- Cyclosporin + Seladelpar Moderate
- Fluconazole + Seladelpar Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Rifampicin with Seladelpar?
MediHelp rates the interaction as moderate. Rifampicin and Seladelpar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin lowers seladelpar concentrations, which may delay or diminish the biochemical response in cholangitis.
How serious is the interaction between Rifampicin and Seladelpar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALP and bilirubin when rifampicin is started. Evaluate the need for therapy change if response is lost.
What other medicines interact with Seladelpar?
MediHelp also lists interactions of Seladelpar with, for example, Cyclosporin, Fluconazole. The full list is on the Seladelpar page.
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