Drug interactions
Fluconazole + Seladelpar
Severity: Moderate
Fluconazole and Seladelpar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole increases seladelpar exposure, which may raise the risk of adverse effects such as liver enzyme elevation.
What this interaction means in plain words
Fluconazole and Seladelpar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Seladelpar belongs to Gastrointestinal Tract.
Why it happens
Fluconazole inhibits both CYP2C9 and CYP3A4, the enzymes that metabolize seladelpar.
What to do
Monitor for adverse effects and liver tests during co-administration. Avoid prolonged combination where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluconazole and Seladelpar, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Seladelpar
- Cyclosporin + Seladelpar Moderate
- Rifampicin + Seladelpar Moderate
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Seladelpar?
MediHelp rates the interaction as moderate. Fluconazole and Seladelpar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole increases seladelpar exposure, which may raise the risk of adverse effects such as liver enzyme elevation.
How serious is the interaction between Fluconazole and Seladelpar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and liver tests during co-administration. Avoid prolonged combination where possible.
What other medicines interact with Seladelpar?
MediHelp also lists interactions of Seladelpar with, for example, Cyclosporin, Rifampicin. The full list is on the Seladelpar page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
