Drug interactions
Cyclosporin + Tamsulosin
Severity: Moderate
Cyclosporin and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase tamsulosin concentrations, raising the risk of orthostatic hypotension, dizziness and syncope. The effect is predicted from CYP3A4 inhibition and has little direct study.
What this interaction means in plain words
Cyclosporin and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Tamsulosin belongs to Genitourinary.
Why it happens
Cyclosporine inhibits CYP3A4 metabolism of tamsulosin.
What to do
Counsel on rising slowly and monitor for dizziness or low blood pressure; reduce the tamsulosin dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Frequently asked questions
Can I take Cyclosporin with Tamsulosin?
MediHelp rates the interaction as moderate. Cyclosporin and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may increase tamsulosin concentrations, raising the risk of orthostatic hypotension, dizziness and syncope. The effect is predicted from CYP3A4 inhibition and has little direct study.
How serious is the interaction between Cyclosporin and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on rising slowly and monitor for dizziness or low blood pressure; reduce the tamsulosin dose if symptoms occur.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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