Drug interactions
Cyclosporin + Tinidazole
Severity: Moderate
Cyclosporin and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroimidazoles such as metronidazole have been reported to raise cyclosporine levels, and tinidazole may behave similarly. Increased levels may cause nephrotoxicity, tremor and other calcineurin-inhibitor toxicity.
What this interaction means in plain words
Cyclosporin and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Tinidazole belongs to Anti Parasitic.
Why it happens
The mechanism is not well established, but inhibition of cyclosporine metabolism is suspected based on related nitroimidazoles.
What to do
Check cyclosporine trough levels and renal function during and after the tinidazole course, and reduce the dose if levels are high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Cyclosporin with Tinidazole?
MediHelp rates the interaction as moderate. Cyclosporin and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroimidazoles such as metronidazole have been reported to raise cyclosporine levels, and tinidazole may behave similarly. Increased levels may cause nephrotoxicity, tremor and other calcineurin-inhibitor toxicity.
How serious is the interaction between Cyclosporin and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check cyclosporine trough levels and renal function during and after the tinidazole course, and reduce the dose if levels are high.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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