Drug interactions
Cyclosporin + Tolazamide
Severity: Minor
Cyclosporin and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may alter the glucose-lowering effect of sulfonylureas, and sulfonylureas may change cyclosporine levels, though reports are inconsistent. Cyclosporine can also impair insulin secretion and cause hyperglycemia.
What this interaction means in plain words
Cyclosporin and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Tolazamide belongs to Endocrine.
Why it happens
The mechanism is not well established; cyclosporine-related effects on glucose handling and possible metabolic interference.
What to do
Monitor blood glucose and adjust the sulfonylurea dose as needed, and check cyclosporine levels if the sulfonylurea is changed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Cyclosporin with Tolazamide?
MediHelp rates the interaction as minor. Cyclosporin and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporine may alter the glucose-lowering effect of sulfonylureas, and sulfonylureas may change cyclosporine levels, though reports are inconsistent. Cyclosporine can also impair insulin secretion and cause hyperglycemia.
How serious is the interaction between Cyclosporin and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and adjust the sulfonylurea dose as needed, and check cyclosporine levels if the sulfonylurea is changed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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