Drug interactions
Cyclosporin + Ustekinumab
Severity: Moderate
Cyclosporin and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining cyclosporine with ustekinumab may add to immunosuppression and the risk of infection. Ustekinumab has not been studied with immunosuppressants other than methotrexate in a systematic way, and the overall risk is likely modest.
What this interaction means in plain words
Cyclosporin and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from calcineurin inhibition and IL-12/23 blockade.
What to do
Monitor for signs of infection and reassess the need for ongoing combined immunosuppression regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Cyclosporin with Ustekinumab?
MediHelp rates the interaction as moderate. Cyclosporin and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining cyclosporine with ustekinumab may add to immunosuppression and the risk of infection. Ustekinumab has not been studied with immunosuppressants other than methotrexate in a systematic way, and the overall risk is likely modest.
How serious is the interaction between Cyclosporin and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and reassess the need for ongoing combined immunosuppression regularly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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