Drug interactions
Cyclosporin + Vinblastine
Severity: Major
Cyclosporin and Vinblastine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin inhibits P-glycoprotein and CYP3A4 and may raise vinblastine exposure, increasing the risk of myelosuppression, neurotoxicity and constipation or ileus. Vinblastine toxicity can be severe.
What this interaction means in plain words
Cyclosporin and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Vinblastine belongs to Oncology.
Why it happens
Cyclosporin inhibits P-glycoprotein efflux and CYP3A4 metabolism of vinblastine.
What to do
Avoid the combination where possible or reduce the vinblastine dose. Monitor blood counts and neurological and gastrointestinal toxicity closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Vinblastine
Frequently asked questions
Can I take Cyclosporin with Vinblastine?
MediHelp rates the interaction as major. Cyclosporin and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporin inhibits P-glycoprotein and CYP3A4 and may raise vinblastine exposure, increasing the risk of myelosuppression, neurotoxicity and constipation or ileus. Vinblastine toxicity can be severe.
How serious is the interaction between Cyclosporin and Vinblastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible or reduce the vinblastine dose. Monitor blood counts and neurological and gastrointestinal toxicity closely.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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