Drug interactions
Voclosporin + Voriconazole
Severity: Contraindicated
Voclosporin and Voriconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole raises voclosporin concentrations considerably, increasing risk of nephrotoxicity, hypertension, hyperkalemia, neurotoxicity and over-immunosuppression.
What this interaction means in plain words
Voclosporin and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Voclosporin belongs to Miscellaneous; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition decreases the metabolism of voclosporin.
What to do
Avoid concomitant use as voclosporin labeling prohibits strong CYP3A4 inhibitors. Consider a non-azole antifungal option.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Voclosporin with Voriconazole?
MediHelp rates the interaction as contraindicated. Voclosporin and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole raises voclosporin concentrations considerably, increasing risk of nephrotoxicity, hypertension, hyperkalemia, neurotoxicity and over-immunosuppression.
How serious is the interaction between Voclosporin and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use as voclosporin labeling prohibits strong CYP3A4 inhibitors. Consider a non-azole antifungal option.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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