Drug interactions
Cyclosporin + Ziprasidone
Severity: Moderate
Cyclosporin and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone is partly metabolized by CYP3A4, but most clearance is via aldehyde oxidase, so cyclosporine is expected to raise levels only modestly. Ziprasidone prolongs the QT interval, so any increase in exposure or electrolyte disturbance from cyclosporine, such as hypomagnesemia, may add risk.
What this interaction means in plain words
Cyclosporin and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Ziprasidone belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by cyclosporine may raise ziprasidone levels, adding to QT-related risk, with cyclosporine-induced electrolyte disturbances as a further contributor.
What to do
Check baseline ECG, potassium and magnesium, and correct any abnormalities. Repeat the ECG if the dose is raised or if symptoms of arrhythmia appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Cyclosporin with Ziprasidone?
MediHelp rates the interaction as moderate. Cyclosporin and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone is partly metabolized by CYP3A4, but most clearance is via aldehyde oxidase, so cyclosporine is expected to raise levels only modestly. Ziprasidone prolongs the QT interval, so any increase in exposure or electrolyte disturbance from cyclosporine, such as hypomagnesemia, may add risk.
How serious is the interaction between Cyclosporin and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG, potassium and magnesium, and correct any abnormalities. Repeat the ECG if the dose is raised or if symptoms of arrhythmia appear.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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