Drug interactions
Cyclosporine + Hydrochlorothiazide-lisinopril
Severity: Moderate
Cyclosporine and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides combined with cyclosporine may increase the risk of hyperuricemia and gout, and thiazide-induced electrolyte disturbances such as hyponatremia can be worsened. Cyclosporine nephrotoxicity can also be aggravated by volume depletion. Lisinopril with cyclosporine adds a risk of hyperkalemia and renal impairment.
What this interaction means in plain words
Cyclosporine and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on electrolytes, renal function and uric acid handling, with cyclosporine-related renal vasoconstriction and potassium retention.
What to do
Monitor serum sodium, potassium, creatinine and uric acid regularly, and check cyclosporine trough levels. Correct volume depletion and adjust therapy if electrolytes or renal function deteriorate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Cyclosporine with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Cyclosporine and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides combined with cyclosporine may increase the risk of hyperuricemia and gout, and thiazide-induced electrolyte disturbances such as hyponatremia can be worsened. Cyclosporine nephrotoxicity can also be aggravated by volume depletion. Lisinopril with cyclosporine adds a risk of hyperkalemia and renal impairment.
How serious is the interaction between Cyclosporine and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium, potassium, creatinine and uric acid regularly, and check cyclosporine trough levels. Correct volume depletion and adjust therapy if electrolytes or renal function deteriorate.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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