Drug interactions
Cyproheptadine + Gabapentin enacarbil
Severity: Moderate
Cyproheptadine and Gabapentin enacarbil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin enacarbil is converted to gabapentin and causes somnolence and dizziness. Cyproheptadine adds sedation, and combining CNS depressants may contribute to respiratory depression, particularly in older or compromised patients.
What this interaction means in plain words
Cyproheptadine and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression. Take extra care in older adults and in patients with lung disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Cyproheptadine with Gabapentin enacarbil?
MediHelp rates the interaction as moderate. Cyproheptadine and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin enacarbil is converted to gabapentin and causes somnolence and dizziness. Cyproheptadine adds sedation, and combining CNS depressants may contribute to respiratory depression, particularly in older or compromised patients.
How serious is the interaction between Cyproheptadine and Gabapentin enacarbil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Take extra care in older adults and in patients with lung disease.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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