Drug interactions
Cyproheptadine + Lemborexant
Severity: Moderate
Cyproheptadine and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating, and combined use may increase somnolence and next-day impairment of alertness and psychomotor performance.
What this interaction means in plain words
Cyproheptadine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Lemborexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and orexin receptor antagonism.
What to do
Warn the patient about residual sedation and driving risk, and reduce the lemborexant dose if daytime impairment occurs. Avoid combining with other sedatives where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Cyproheptadine with Lemborexant?
MediHelp rates the interaction as moderate. Cyproheptadine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating, and combined use may increase somnolence and next-day impairment of alertness and psychomotor performance.
How serious is the interaction between Cyproheptadine and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about residual sedation and driving risk, and reduce the lemborexant dose if daytime impairment occurs. Avoid combining with other sedatives where possible.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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