Drug interactions
Cyproheptadine + Maprotiline
Severity: Moderate
Cyproheptadine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and have anticholinergic activity, so combining them can intensify drowsiness, impair psychomotor performance and increase anticholinergic effects such as dry mouth, urinary retention and constipation. Elderly patients are at greatest risk.
What this interaction means in plain words
Cyproheptadine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression through histamine H1 blockade plus additive antimuscarinic effects.
What to do
Monitor for excessive sedation and anticholinergic effects, particularly in older adults, and advise against driving. Reduce the dose of one agent if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Cyproheptadine with Maprotiline?
MediHelp rates the interaction as moderate. Cyproheptadine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and have anticholinergic activity, so combining them can intensify drowsiness, impair psychomotor performance and increase anticholinergic effects such as dry mouth, urinary retention and constipation. Elderly patients are at greatest risk.
How serious is the interaction between Cyproheptadine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and anticholinergic effects, particularly in older adults, and advise against driving. Reduce the dose of one agent if symptoms develop.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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