Drug interactions
Cyproheptadine + Naratriptan
Severity: Minor
Cyproheptadine and Naratriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine's serotonin receptor blockade could in theory reduce the antimigraine effect of naratriptan. Clinical evidence of a meaningful loss of efficacy is limited.
What this interaction means in plain words
Cyproheptadine and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyproheptadine belongs to Respiratory; Naratriptan belongs to Central Nervous System.
Why it happens
Theoretical pharmacodynamic antagonism of serotonin receptor activity by cyproheptadine.
What to do
Monitor migraine response; if naratriptan appears less effective, review whether cyproheptadine can be stopped or spaced from dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Cyproheptadine with Naratriptan?
MediHelp rates the interaction as minor. Cyproheptadine and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyproheptadine's serotonin receptor blockade could in theory reduce the antimigraine effect of naratriptan. Clinical evidence of a meaningful loss of efficacy is limited.
How serious is the interaction between Cyproheptadine and Naratriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor migraine response; if naratriptan appears less effective, review whether cyproheptadine can be stopped or spaced from dosing.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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