Drug interactions
Cyproheptadine + Sumatriptan
Severity: Moderate
Cyproheptadine and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine's serotonin receptor blockade may reduce the effectiveness of sumatriptan in aborting migraine. Clinical data are limited, and no serious toxicity is expected from the combination.
What this interaction means in plain words
Cyproheptadine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Sumatriptan belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism of serotonin receptors by cyproheptadine, opposing triptan 5-HT1B/1D agonism.
What to do
Monitor for reduced headache relief after sumatriptan. If response is inadequate, review whether cyproheptadine is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyproheptadine and Sumatriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Cyproheptadine with Sumatriptan?
MediHelp rates the interaction as moderate. Cyproheptadine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyproheptadine's serotonin receptor blockade may reduce the effectiveness of sumatriptan in aborting migraine. Clinical data are limited, and no serious toxicity is expected from the combination.
How serious is the interaction between Cyproheptadine and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced headache relief after sumatriptan. If response is inadequate, review whether cyproheptadine is needed.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
