Drug interactions
Cytarabine + Trastuzumab deruxtecan
Severity: Moderate
Cytarabine and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan commonly causes neutropenia, and adding myelosuppressive cytarabine can increase the incidence and severity of neutropenia and febrile neutropenia. Infection risk rises accordingly.
What this interaction means in plain words
Cytarabine and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cytarabine belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression from the topoisomerase I inhibitor payload and cytarabine.
What to do
Monitor complete blood counts closely and follow dose-modification guidance for neutropenia. Consider growth factor support and prompt evaluation of fever.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cytarabine
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Cytarabine with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Cytarabine and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan commonly causes neutropenia, and adding myelosuppressive cytarabine can increase the incidence and severity of neutropenia and febrile neutropenia. Infection risk rises accordingly.
How serious is the interaction between Cytarabine and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and follow dose-modification guidance for neutropenia. Consider growth factor support and prompt evaluation of fever.
What other medicines interact with Cytarabine?
MediHelp also lists interactions of Cytarabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Cytarabine page.
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