Drug interactions
Dabigatran + Dalteparin
Severity: Major
Dabigatran and Dalteparin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are anticoagulants, so using them together considerably raises the risk of serious bleeding. Concurrent use is generally limited to deliberate transitions between agents.
What this interaction means in plain words
Dabigatran and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive anticoagulation through factor Xa inhibition (via antithrombin) by dalteparin and direct thrombin inhibition by dabigatran.
What to do
Avoid concurrent use except when switching; when changing, start dabigatran at the time the next scheduled dalteparin dose would be due, and monitor for bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dabigatran with Dalteparin?
MediHelp rates the interaction as major. Dabigatran and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are anticoagulants, so using them together considerably raises the risk of serious bleeding. Concurrent use is generally limited to deliberate transitions between agents.
How serious is the interaction between Dabigatran and Dalteparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use except when switching; when changing, start dabigatran at the time the next scheduled dalteparin dose would be due, and monitor for bleeding and renal function.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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