Drug interactions
Dabigatran + Liposomal doxorubicin
Severity: Minor
Dabigatran and Liposomal doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is a P-gp substrate and has been described as a possible P-gp inducer or competitor, but no reliable reduction in dabigatran exposure is established. Chemotherapy-related thrombocytopenia is the more important issue with anticoagulants.
What this interaction means in plain words
Dabigatran and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible effect on P-gp-mediated dabigatran efflux, not clearly established.
What to do
No dose change is needed on this basis; monitor platelet count and renal function, and review dabigatran use if thrombocytopenia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Frequently asked questions
Can I take Dabigatran with Liposomal doxorubicin?
MediHelp rates the interaction as minor. Dabigatran and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxorubicin is a P-gp substrate and has been described as a possible P-gp inducer or competitor, but no reliable reduction in dabigatran exposure is established. Chemotherapy-related thrombocytopenia is the more important issue with anticoagulants.
How serious is the interaction between Dabigatran and Liposomal doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed on this basis; monitor platelet count and renal function, and review dabigatran use if thrombocytopenia occurs.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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