Drug interactions
Dabigatran + Mefloquine
Severity: Moderate
Dabigatran and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine may inhibit intestinal P-glycoprotein and raise dabigatran exposure. Higher dabigatran levels increase the risk of bleeding, especially in patients with reduced renal function.
What this interaction means in plain words
Dabigatran and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein efflux of dabigatran etexilate increases its absorption.
What to do
Monitor for bleeding and renal function. Follow dabigatran labeling that advises avoiding P-gp inhibitors in patients with significant renal impairment (CrCl below 30 mL/min for atrial fibrillation, below 50 mL/min for DVT/PE treatment).
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Dabigatran with Mefloquine?
MediHelp rates the interaction as moderate. Dabigatran and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine may inhibit intestinal P-glycoprotein and raise dabigatran exposure. Higher dabigatran levels increase the risk of bleeding, especially in patients with reduced renal function.
How serious is the interaction between Dabigatran and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function. Follow dabigatran labeling that advises avoiding P-gp inhibitors in patients with significant renal impairment (CrCl below 30 mL/min for atrial fibrillation, below 50 mL/min for DVT/PE treatment).
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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