Drug interactions
Dabigatran etexilate + Diflunisal
Severity: Major
Dabigatran etexilate and Diflunisal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal is an NSAID that impairs platelet function and can cause gastrointestinal injury, raising bleeding risk with dabigatran. Its effect on renal function may also increase dabigatran exposure.
What this interaction means in plain words
Dabigatran etexilate and Diflunisal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabigatran etexilate belongs to Cardiovascular; Diflunisal belongs to Musculoskeletal.
Why it happens
Additive effects on hemostasis from NSAID-mediated platelet inhibition and mucosal injury with direct thrombin inhibition.
What to do
Avoid the combination where possible and use a non-NSAID analgesic. If unavoidable, monitor for bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Dabigatran etexilate with Diflunisal?
MediHelp rates the interaction as major. Dabigatran etexilate and Diflunisal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diflunisal is an NSAID that impairs platelet function and can cause gastrointestinal injury, raising bleeding risk with dabigatran. Its effect on renal function may also increase dabigatran exposure.
How serious is the interaction between Dabigatran etexilate and Diflunisal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use a non-NSAID analgesic. If unavoidable, monitor for bleeding and renal function.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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