Drug interactions
Dabigatran etexilate + Etodolac
Severity: Major
Dabigatran etexilate and Etodolac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac is an NSAID that can cause gastrointestinal mucosal injury and platelet inhibition, increasing bleeding risk with dabigatran. NSAID-related renal impairment may also increase dabigatran exposure.
What this interaction means in plain words
Dabigatran etexilate and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabigatran etexilate belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment from NSAID effects with direct thrombin inhibition, plus possible reduced dabigatran renal clearance.
What to do
Avoid regular use and prefer paracetamol. If needed, use the lowest dose briefly with gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Dabigatran etexilate with Etodolac?
MediHelp rates the interaction as major. Dabigatran etexilate and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etodolac is an NSAID that can cause gastrointestinal mucosal injury and platelet inhibition, increasing bleeding risk with dabigatran. NSAID-related renal impairment may also increase dabigatran exposure.
How serious is the interaction between Dabigatran etexilate and Etodolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use and prefer paracetamol. If needed, use the lowest dose briefly with gastroprotection and monitor for bleeding.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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