Drug interactions
Dabigatran etexilate + Ketoprofen
Severity: Moderate
Dabigatran etexilate and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen reduces platelet aggregation and can damage the gastric lining, so it adds to the bleeding risk of dabigatran. The risk is higher in older adults and patients with reduced kidney function.
What this interaction means in plain words
Dabigatran etexilate and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
Additive effect on hemostasis: NSAID platelet inhibition and mucosal injury with thrombin inhibition.
What to do
Use an alternative analgesic such as paracetamol where possible. If an NSAID is required, use the lowest dose briefly and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Dabigatran etexilate with Ketoprofen?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoprofen reduces platelet aggregation and can damage the gastric lining, so it adds to the bleeding risk of dabigatran. The risk is higher in older adults and patients with reduced kidney function.
How serious is the interaction between Dabigatran etexilate and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative analgesic such as paracetamol where possible. If an NSAID is required, use the lowest dose briefly and monitor for bleeding.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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