Drug interactions
Dabigatran etexilate + Lapatinib
Severity: Moderate
Dabigatran etexilate and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits intestinal P-glycoprotein and may increase absorption of dabigatran etexilate, raising dabigatran concentrations and bleeding risk. The effect is more relevant with renal impairment.
What this interaction means in plain words
Dabigatran etexilate and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Lapatinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux of dabigatran etexilate in the gut.
What to do
Monitor for bleeding and renal function. Avoid the combination in patients with significantly reduced creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Dabigatran etexilate with Lapatinib?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits intestinal P-glycoprotein and may increase absorption of dabigatran etexilate, raising dabigatran concentrations and bleeding risk. The effect is more relevant with renal impairment.
How serious is the interaction between Dabigatran etexilate and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function. Avoid the combination in patients with significantly reduced creatinine clearance.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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