Drug interactions
Dabigatran etexilate + Neratinib
Severity: Moderate
Dabigatran etexilate and Neratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neratinib inhibits P-glycoprotein and may raise dabigatran concentrations. Higher exposure increases the risk of bleeding.
What this interaction means in plain words
Dabigatran etexilate and Neratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Neratinib belongs to Oncology.
Why it happens
Neratinib inhibits intestinal P-glycoprotein, increasing dabigatran etexilate absorption.
What to do
Monitor for bleeding and renal function; consider a dabigatran dose reduction or separating doses by several hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Neratinib
- Amiodarone + Neratinib Major
- Amobarbital + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Bosentan + Neratinib Major
- Carbamazepine + Neratinib Major
Frequently asked questions
Can I take Dabigatran etexilate with Neratinib?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Neratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neratinib inhibits P-glycoprotein and may raise dabigatran concentrations. Higher exposure increases the risk of bleeding.
How serious is the interaction between Dabigatran etexilate and Neratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function; consider a dabigatran dose reduction or separating doses by several hours.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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