Drug interactions
Dabigatran etexilate + Nicardipine
Severity: Moderate
Dabigatran etexilate and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits P-glycoprotein and may modestly raise dabigatran exposure, increasing bleeding risk. The effect is most relevant with reduced renal function.
What this interaction means in plain words
Dabigatran etexilate and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux of dabigatran etexilate.
What to do
Monitor for bleeding and renal function. Avoid the combination if creatinine clearance is reduced below labeled thresholds.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Dabigatran etexilate with Nicardipine?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine inhibits P-glycoprotein and may modestly raise dabigatran exposure, increasing bleeding risk. The effect is most relevant with reduced renal function.
How serious is the interaction between Dabigatran etexilate and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function. Avoid the combination if creatinine clearance is reduced below labeled thresholds.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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