Drug interactions
Dabigatran etexilate + Sarecycline
Severity: Minor
Dabigatran etexilate and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is a tetracycline-class acne drug with in vitro P-gp inhibition, so a small rise in dabigatran exposure is theoretically possible. Systemic exposure to sarecycline is low and clinically relevant effects are unlikely.
What this interaction means in plain words
Dabigatran etexilate and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabigatran etexilate belongs to Cardiovascular; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible weak P-glycoprotein inhibition by sarecycline reducing dabigatran etexilate efflux.
What to do
No dose adjustment is needed; watch for bleeding in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Dabigatran etexilate with Sarecycline?
MediHelp rates the interaction as minor. Dabigatran etexilate and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is a tetracycline-class acne drug with in vitro P-gp inhibition, so a small rise in dabigatran exposure is theoretically possible. Systemic exposure to sarecycline is low and clinically relevant effects are unlikely.
How serious is the interaction between Dabigatran etexilate and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; watch for bleeding in patients with renal impairment.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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