Drug interactions
Dabigatran etexilate + Sulindac
Severity: Moderate
Dabigatran etexilate and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as sulindac impair platelet function and can irritate the gastrointestinal mucosa, so adding one to dabigatran increases the likelihood of bleeding, especially gastrointestinal bleeding.
What this interaction means in plain words
Dabigatran etexilate and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment: dabigatran inhibits thrombin while sulindac inhibits platelet cyclooxygenase and damages gastric mucosa.
What to do
Avoid NSAIDs where possible and use paracetamol or another alternative. If needed, use the lowest dose for the shortest time and monitor for bleeding, considering gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Dabigatran etexilate with Sulindac?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as sulindac impair platelet function and can irritate the gastrointestinal mucosa, so adding one to dabigatran increases the likelihood of bleeding, especially gastrointestinal bleeding.
How serious is the interaction between Dabigatran etexilate and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible and use paracetamol or another alternative. If needed, use the lowest dose for the shortest time and monitor for bleeding, considering gastroprotection.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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