Drug interactions
Dabrafenib + Dapsone
Severity: Minor
Dabrafenib and Dapsone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and other enzymes, which may reduce dapsone concentrations. This could diminish dapsone efficacy, for example in prophylaxis or dermatological use.
What this interaction means in plain words
Dabrafenib and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Dapsone belongs to Anti Bacterial.
Why it happens
Dabrafenib induces CYP3A4, accelerating the hepatic and intestinal metabolism of dapsone.
What to do
Monitor for reduced dapsone efficacy during concurrent use. Adjust the dapsone dose if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Dapsone?
MediHelp rates the interaction as minor. Dabrafenib and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and other enzymes, which may reduce dapsone concentrations. This could diminish dapsone efficacy, for example in prophylaxis or dermatological use.
How serious is the interaction between Dabrafenib and Dapsone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced dapsone efficacy during concurrent use. Adjust the dapsone dose if the response is inadequate.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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