Drug interactions
Dabrafenib + Dasatinib
Severity: Moderate
Dabrafenib and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower dasatinib levels, potentially reducing efficacy.
What this interaction means in plain words
Dabrafenib and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Dasatinib belongs to Oncology.
Why it happens
Dabrafenib induction of CYP3A4 increases dasatinib metabolism.
What to do
Monitor treatment response and consider a higher dasatinib dose, or use an alternative to dabrafenib if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Dasatinib?
MediHelp rates the interaction as moderate. Dabrafenib and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower dasatinib levels, potentially reducing efficacy.
How serious is the interaction between Dabrafenib and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response and consider a higher dasatinib dose, or use an alternative to dabrafenib if feasible.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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