Drug interactions
Dabrafenib + Dronabinol
Severity: Moderate
Dabrafenib and Dronabinol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and CYP2C9 and may lower dronabinol concentrations. This could reduce the antiemetic or appetite-stimulating effect.
What this interaction means in plain words
Dabrafenib and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Dronabinol belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 and CYP2C9 increases dronabinol metabolism.
What to do
Monitor clinical response and increase the dronabinol dose if efficacy is lost. Reassess the dose when dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Dronabinol?
MediHelp rates the interaction as moderate. Dabrafenib and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and CYP2C9 and may lower dronabinol concentrations. This could reduce the antiemetic or appetite-stimulating effect.
How serious is the interaction between Dabrafenib and Dronabinol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the dronabinol dose if efficacy is lost. Reassess the dose when dabrafenib is stopped.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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