Drug interactions
Dabrafenib + Dronedarone
Severity: Moderate
Dabrafenib and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may substantially lower dronedarone levels, leading to loss of efficacy. Dabrafenib itself may be affected by the interaction as well.
What this interaction means in plain words
Dabrafenib and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Dronedarone belongs to Cardiovascular.
Why it happens
CYP3A4 induction by dabrafenib increases dronedarone clearance.
What to do
Monitor heart rhythm and consider an alternative antiarrhythmic if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Dronedarone?
MediHelp rates the interaction as moderate. Dabrafenib and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may substantially lower dronedarone levels, leading to loss of efficacy. Dabrafenib itself may be affected by the interaction as well.
How serious is the interaction between Dabrafenib and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rhythm and consider an alternative antiarrhythmic if control is lost.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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