Drug interactions
Dabrafenib + Eplerenone
Severity: Moderate
Dabrafenib and Eplerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and eplerenone is cleared mainly by CYP3A4. Concomitant use may lower eplerenone exposure and reduce its effect.
What this interaction means in plain words
Dabrafenib and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Eplerenone belongs to Cardiovascular.
Why it happens
CYP3A4 induction by dabrafenib, increasing eplerenone metabolism.
What to do
Monitor blood pressure and potassium, and increase the eplerenone dose if the response is inadequate. Reassess when dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Eplerenone?
MediHelp rates the interaction as moderate. Dabrafenib and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and eplerenone is cleared mainly by CYP3A4. Concomitant use may lower eplerenone exposure and reduce its effect.
How serious is the interaction between Dabrafenib and Eplerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and potassium, and increase the eplerenone dose if the response is inadequate. Reassess when dabrafenib is stopped.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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