Drug interactions
Dabrafenib + Haloperidol
Severity: Moderate
Dabrafenib and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and can reduce haloperidol concentrations, potentially lessening antipsychotic control. Both drugs can also prolong the QT interval, so ECG changes may still occur.
What this interaction means in plain words
Dabrafenib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Haloperidol belongs to Central Nervous System.
Why it happens
CYP3A4 induction by dabrafenib lowering haloperidol levels, plus additive QT prolongation.
What to do
Monitor psychiatric response and consider haloperidol dose increases if efficacy falls. Check ECG and electrolytes at baseline and periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabrafenib and Haloperidol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Haloperidol?
MediHelp rates the interaction as moderate. Dabrafenib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and can reduce haloperidol concentrations, potentially lessening antipsychotic control. Both drugs can also prolong the QT interval, so ECG changes may still occur.
How serious is the interaction between Dabrafenib and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and consider haloperidol dose increases if efficacy falls. Check ECG and electrolytes at baseline and periodically.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
