Drug interactions
Dabrafenib + Itraconazole
Severity: Major
Dabrafenib and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can raise dabrafenib concentrations, since dabrafenib is metabolized by CYP3A4 and CYP2C8. Both drugs can also prolong the QT interval, so toxicity and arrhythmia risk may both rise.
What this interaction means in plain words
Dabrafenib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
CYP3A4 (and P-gp) inhibition by itraconazole decreases dabrafenib clearance, with additive QT prolongation.
What to do
Avoid the combination where possible and choose a non-inhibiting antifungal. If it must be used, monitor ECG and electrolytes and watch for dabrafenib adverse effects such as fever and skin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Itraconazole?
MediHelp rates the interaction as major. Dabrafenib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole can raise dabrafenib concentrations, since dabrafenib is metabolized by CYP3A4 and CYP2C8. Both drugs can also prolong the QT interval, so toxicity and arrhythmia risk may both rise.
How serious is the interaction between Dabrafenib and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a non-inhibiting antifungal. If it must be used, monitor ECG and electrolytes and watch for dabrafenib adverse effects such as fever and skin toxicity.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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