Drug interactions
Dabrafenib + Ivabradine
Severity: Moderate
Dabrafenib and Ivabradine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower ivabradine concentrations. This can reduce its heart rate lowering effect.
What this interaction means in plain words
Dabrafenib and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Ivabradine belongs to Cardiovascular.
Why it happens
CYP3A4 induction by dabrafenib increases ivabradine clearance.
What to do
Monitor heart rate and symptoms, and titrate ivabradine to effect. Reassess the dose after dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Ivabradine?
MediHelp rates the interaction as moderate. Dabrafenib and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower ivabradine concentrations. This can reduce its heart rate lowering effect.
How serious is the interaction between Dabrafenib and Ivabradine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and symptoms, and titrate ivabradine to effect. Reassess the dose after dabrafenib is stopped.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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