Drug interactions
Dabrafenib + Liposomal doxorubicin
Severity: Minor
Dabrafenib and Liposomal doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower exposure to co-administered drugs that are partly metabolized by this enzyme. Liposomal doxorubicin is cleared mainly by the reticuloendothelial system rather than CYP3A4, so a clinically meaningful loss of effect is unlikely.
What this interaction means in plain words
Dabrafenib and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Liposomal doxorubicin belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, which plays only a small role in doxorubicin disposition.
What to do
No dose change is generally needed. Monitor treatment response and toxicity as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Liposomal doxorubicin?
MediHelp rates the interaction as minor. Dabrafenib and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and may lower exposure to co-administered drugs that are partly metabolized by this enzyme. Liposomal doxorubicin is cleared mainly by the reticuloendothelial system rather than CYP3A4, so a clinically meaningful loss of effect is unlikely.
How serious is the interaction between Dabrafenib and Liposomal doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor treatment response and toxicity as usual.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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