Drug interactions
Dabrafenib + Losartan
Severity: Minor
Dabrafenib and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and CYP2C9, which may lower exposure to losartan and its active metabolite. Blood pressure control may be reduced.
What this interaction means in plain words
Dabrafenib and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Losartan belongs to Cardiovascular.
Why it happens
Dabrafenib induction of CYP3A4 and CYP2C9 enhancing losartan metabolism.
What to do
Monitor blood pressure during and after dabrafenib therapy and increase losartan dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Losartan?
MediHelp rates the interaction as minor. Dabrafenib and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and CYP2C9, which may lower exposure to losartan and its active metabolite. Blood pressure control may be reduced.
How serious is the interaction between Dabrafenib and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during and after dabrafenib therapy and increase losartan dose if needed.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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