Drug interactions
Dabrafenib + Lurasidone
Severity: Moderate
Dabrafenib and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and can reduce lurasidone exposure, potentially leading to relapse of psychiatric symptoms.
What this interaction means in plain words
Dabrafenib and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Lurasidone belongs to Central Nervous System.
Why it happens
Dabrafenib induces CYP3A4, accelerating lurasidone metabolism.
What to do
Monitor for reduced efficacy and increase the lurasidone dose if needed after about a week or more of dabrafenib. Reduce back when dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Lurasidone?
MediHelp rates the interaction as moderate. Dabrafenib and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and can reduce lurasidone exposure, potentially leading to relapse of psychiatric symptoms.
How serious is the interaction between Dabrafenib and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy and increase the lurasidone dose if needed after about a week or more of dabrafenib. Reduce back when dabrafenib is stopped.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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