Drug interactions
Dabrafenib + Midazolam
Severity: Moderate
Dabrafenib and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and substantially lowers midazolam exposure, which may result in reduced sedative effect.
What this interaction means in plain words
Dabrafenib and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Midazolam belongs to Central Nervous System.
Why it happens
Dabrafenib induces CYP3A4, accelerating the metabolism of midazolam.
What to do
Monitor for loss of effect and increase the midazolam dose if required. Re-evaluate the dose after dabrafenib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Midazolam?
MediHelp rates the interaction as moderate. Dabrafenib and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and substantially lowers midazolam exposure, which may result in reduced sedative effect.
How serious is the interaction between Dabrafenib and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of effect and increase the midazolam dose if required. Re-evaluate the dose after dabrafenib is discontinued.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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