Drug interactions
Dabrafenib + Omeprazole
Severity: Moderate
Dabrafenib and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib capsules dissolve less well at higher gastric pH, so acid suppression may lower its absorption and efficacy. Dabrafenib also induces CYP enzymes including CYP2C19 and CYP3A4, which can lower omeprazole exposure and reduce acid suppression.
What this interaction means in plain words
Dabrafenib and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Omeprazole raises gastric pH, reducing dabrafenib solubility, while dabrafenib induces CYP2C19 and CYP3A4, increasing omeprazole clearance.
What to do
Monitor tumour response and reflux symptoms, and consider an alternative to the PPI such as a lower-impact acid suppressant if feasible. Increase omeprazole dose if acid control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Omeprazole?
MediHelp rates the interaction as moderate. Dabrafenib and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib capsules dissolve less well at higher gastric pH, so acid suppression may lower its absorption and efficacy. Dabrafenib also induces CYP enzymes including CYP2C19 and CYP3A4, which can lower omeprazole exposure and reduce acid suppression.
How serious is the interaction between Dabrafenib and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumour response and reflux symptoms, and consider an alternative to the PPI such as a lower-impact acid suppressant if feasible. Increase omeprazole dose if acid control is inadequate.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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