Drug interactions
Dabrafenib + Rimegepant
Severity: Moderate
Dabrafenib and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and can lower rimegepant concentrations, potentially causing loss of efficacy in migraine.
What this interaction means in plain words
Dabrafenib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Rimegepant belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases rimegepant metabolism.
What to do
Avoid routine concurrent use and select an alternative acute migraine therapy. If used, monitor for reduced response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Rimegepant?
MediHelp rates the interaction as moderate. Dabrafenib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and can lower rimegepant concentrations, potentially causing loss of efficacy in migraine.
How serious is the interaction between Dabrafenib and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use and select an alternative acute migraine therapy. If used, monitor for reduced response.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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